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Category:Effect of CYP2C9 genotypes on oral biotransformation of lansoprazole, the active metabolite of lansoprazole.
To investigate the effect of CYP2C9 genotypes on oral biotransformation of lansoprazole, the active metabolite of lansoprazole, from in vitro experiments using human liver microsomes and from single-dose, randomized, open-label study in healthy volunteers. Phase I and II studies were conducted in healthy volunteers. CYP2C9 genotypes were determined by PCR-RFLP. In vitro experiments using human liver microsomes were conducted in four non-carriers and two heterozygous carriers of CYP2C9*2 and *3. In vivo studies were conducted with four non-carriers and four heterozygous carriers of CYP2C9*2 and *3. In vitro studies, formation rate of lansoprazole sulfone metabolite was significantly lower in heterozygous carriers of CYP2C9*2 and *3 than non-carriers of CYP2C9*2 and *3. In vivo studies, AUC(0-24) and C(max) of lansoprazole were significantly lower in the 82fe58eafd
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