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(S.E.S. 50.96) that was isolated from a marine sponge, *Pseudoceratina purpurea* ([@B14]). Shikonin was shown to be an active compound against herpes simplex virus-1 with *in vitro* antiviral activity ([@B5]). In addition, shikonin has cytotoxic activity, and also anti-tumor and immune-modulating activities *in vitro* and *in vivo* ([@B26]). This compound has proven to be effective in preventing neuronal damage and loss in the hippocampus, using an animal model of vascular dementia (VD), because of its ability to inhibit microglia activation ([@B23]; [@B10]). In a recent study, shikonin was used in a hydroalcoholic extract of *Echium vulgare* leaves, which showed a significant activity against *Streptococcus pyogenes*, the main etiologic agent of streptococcal pharyngitis ([@B27]). It was observed that the hydroalcoholic extract and the individual compound shikonin could be used as alternatives to antibiotics in the treatment of the streptococcal infection.
Regarding the antifungal activity observed in the *Eucalyptus* species, it is important to highlight the studies that have been conducted by [@B1], who investigated the effect of a hydroalcoholic extract of *Eucalyptus melliodora* and found that it had no *in vitro* antimicrobial activity. However, [@B21] demonstrated that an essential oil containing up to 19.0% β-ocimene had antibacterial activity against the Gram-positive and Gram-negative microorganisms tested. These results are consistent with our findings of the bioassay-guided isolation of two compounds with antifungal activity, one of them (*a*) thymol and the other (*e*) eucalyptol. The compounds used were the main constituents of *Eucalyptus citriodora* leaf essential oil ([@B7]; [@B
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SRS Audio Sandbox 1.10.2.0 Serial Key keygen Full Crack
File size:
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SRS Audio Sandbox 1.10.2.0 Serial Key keygen
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