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Human splice corrector protein 1 (SC1) is an essential splicing factor that inhibits apoptosis by interacting with caspase 3, which is associated with the promotion of human atherosclerosis. In the present study, we examined the role of SC1 in macrophage-derived foam cell formation. The expression of SC1 was upregulated in THP-1 cells incubated with oxidized low-density lipoprotein. The scavenger receptor (SR)-mediated uptake of acetylated low-density lipoprotein was increased in the presence of SC1. Immunofluorescence staining revealed that SC1 expression was localized in the lipid rafts of THP-1 cells. Furthermore, the level of SC1 was elevated in advanced lesions in human coronary atherosclerotic plaques. In addition, SC1-overexpressing THP-1 cells exhibited an enhanced level of SR-mediated cholesterol uptake. Taken together, these results suggest that upregulation of SC1 may lead to the formation of foam cells by promoting the activity of SRs in macrophages, which might
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GiliSoft Screen Recorder Pro 10.3.0 Crack Download HERE ! [2022-Latest]