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Almost 80-90% of the variability observed in pharmacological responses is attributed to biological and environmental factors. This is not surprising when we consider that these factors account for only 50% of the variability in responses to a drug. Failure of a drug to work in a particular individual is thus largely explained by genetic causes. We have witnessed an exponential increase in the rate of progress in the field of pharmacogenomics in the last decade. A better understanding of the basic mechanisms and the integration of genetic research with better bioinformatics has resulted in novel discoveries that will change the way drugs are developed and used. This review will attempt to cover some of these significant aspects of pharmacogenomics, its benefits and potential pitfalls..
Secondly, I want to make it clear that I am not in favor of mind-blowing speed. I am in favor of speed when it is got on a sound basis. After all, if you want to be the fastest runner in the world, you should probably train hard. But you would probably not be able to make it on sheer speed, unless you were a world-class talent and had the necessary talent or skills.
In the same way, a computer programmer should not code inassembly language. However, we should also not be against assembly languages. They are languages that are highly efficient for specific purposes, and obviously would suit some purposes better than others. However, with the right approach, they can be made to perform just as well as a high-level language.
Perhaps my design of the framework might have been a bit too ambitious? Perhaps there is a better way? Yes, there are many ways to do it. We just need to keep experimenting, keeping up the pace and not hang up. That is the only way we can continue to get better.
Wednesday, September 11, 2007
In the most recent episode of the BBC's series, Great Lives, Maggie Thatcher was interviewed. While the interview was done in a neutral and objective manner, Maggie admitted to being a highly emotional and deep person.
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