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S. GrigoryevMedicineSelskokhozyaistvennaya Biologiya2020Currently, there is a big need in industrial varieties of pharmaceutical specialization (CBD-cultivars). This paper is the first to report on selection of the accessions with high CBD content (above… View 2 excerpts, cites backgroundIn this chapter, cannabis botany, chemistry, its indoor and outdoor cultivation, harvesting, processing and its current status as a botanical drug are addressed.It is suggested that selection for taller and fast-growing genotypes is likely to lead to an increase in floral bud productivity, and a prediction equation for forecasting floral bud dry weight was generated, driven by parameters that can be detected during the vegetative growth phase solely.Research indicates that CBD and several other cannabinoids have potential to treat multiple clinical conditions, but more preclinical, and clinical studies and clinical trials, which follow regulatory guidelines, are needed to formally recommend CBD and other cannabinoids as medicines.C. GrofBiologyBritish journal of clinical pharmacology2018Intensive breeding strategies will provide novel cultivars of cannabis possessing elevated levels of specific cannabinoids or other secondary metabolites, an attribute that has been described as the entourage effect.David Charles Simiyu, J. Jang, O. LeeBiologyPlants2022The beneficial and harmful effects of the prominent phytocannabinoids are described and status of the studies on heterologous synthesis of phytcannabinoids in different biological systems are provided.View 1 excerpt, cites backgroundDariusz Zielonka, Łukasz Kiraga, R. KozłowskiBiology2020The results suggest that more extensive chemical and genetic characterization of the Cannabis genepool could facilitate the metabolic engineering of alkyl cannabinoid chemotypes, indicating a low level of plasticity in cannabinoid composition.View 4 excerpts, cites backgroundSHOWING 1-10 OF 45 REFERENCESSORT BYRelevanceMost Influenced PapersRecencyDavid J PotterMedicineDrug testing and analysis2014To produce the complex botanical medicine Sativex®, which contains the cannabinoids Δ(9)-tetrahydrocannabinol (THC) and cannabidiol (CBD) and a range of other ingredients, GW Pharmaceuticals had to manage these variables.This paper reports a simple and efficient method for the in vitro propagation of a screened and selected high yielding drug type variety of Cannabis sativa, MX-1 using synthetic seed technology and the addition of antimicrobial substance — Plant Preservative Mixture had a positive effect on overall plantlet development.View 1 excerpt, references backgroundE. Meijer, K. HammondBiologyEuphytica2005B0 is considered as a member of the BD allelic series encoding a CBD synthase isoform with greatly weakened substrate affinity andor catalytic capacity, and is plausible that this B0 is a mutation of normally functional BD.E. Meijer, K. Hammond, M. MichelerBiologyEuphytica2008The mechanism that controls the proportion of cannabichromene (CBC), a potential pharmaceutical, in the cannabinoid fraction of Cannabis sativa L. is explored and the ability of PJC plants to enable the production of pharmaceutical raw material with high CBC purity is demonstrated.This contribution presents an overview of the botany, cultivation aspects, and the phytochemistry of cannabis and its chemical constituents, with particular emphasis on the newly-identifiedisolated compounds.View 1 excerpt, references backgroundThe results confirm the clonal fidelity of IVP plants of C. sativa and suggest that the biochemical mechanism used in this study to produce the micropropagated plants does not affect the metabolic content and can be used for the mass propagation of true to type plants of this species for commercial pharmaceutical use.E. Meijer, K. Hammond, A. SuttonBiologyEuphytica2009Backcrossing produced cannabinoid-free homologues of pharmaceutical production clones with potential applications in pharmacological research and suggests that locus O governs a reaction in the pathway towards the phenolic cannabinoid precursors.E. Meijer, L. KeizerBiologyGenetic Resources and Crop Evolution2004SummaryA Cannabis germplasm collection was evaluated for traits relevant to the use of hemp as an arable source of paper pulp. The traits were related to stem yield and quality, psychoactive potency,… View 1 excerpt, references backgroundThe results suggest that the micropropagation protocol developed by us for rapid IN VITRO multiplication is appropriate and applicable for clonal mass propagation of C. SATIVA.GC analysis of six major cannabinoids showed homogeneity in the re-grown clones and the mother plant with insignificant differences in cannabinoids content, thereby confirming the stability of plants derived from synthetic seeds following 6 months storage.View 1 excerpt, references background As studies continue to reveal favorable findings for the use of cannabidiol in the management of childhood epilepsy syndromes and other disorders, best practices for the large-scale production of Cannabis are needed for timely product development and research purposes. The processes of two institutions with extensive experience in producing large-scale cannabidiol chemotype Cannabis crops-GW Pharmaceuticals and the University of Mississippi-are described, including breeding, indoor and outdoor growing, harvesting, and extraction methods. Such practices have yielded desirable outcomes in Cannabis breeding and production: GW Pharmaceuticals has a collection of chemotypes dominant in any one of eight cannabinoids, two of which-cannabidiol and cannabidivarin-are supporting epilepsy clinical trial research, whereas in addition to a germplasm bank of high-THC, high-CBD, and intermediate type cannabis varieties, the team at University of Mississippi has established an in vitro propagation protocol for cannabis with no detectable variations in morphologic, physiologic, biochemical, and genetic profiles as compared to the mother plants. Improvements in phytocannabinoid yields and growing efficiency are expected as research continues at these institutions. This article is part of a Special Issue entitled Cannabinoids and Epilepsy. Keywords: Cannabidiol; Cannabidivarin; Chemotype; Organogenesis; Pharmacognosy; Phytocannabinoid.

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