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Amazon.co.id.Study of the effects of high-dose metronidazole therapy on microcirculation in patients with generalized peritonitis.
The objective of this study was to assess the changes of local microcirculation (LMC) in patients with generalized peritonitis (GP) on high-dose metronidazole therapy (HDMT). The study included 25 patients with GP; 13 received HDMT for the initial and subsequent antibiotic therapy, and 12 received the initial therapy only. LMC was studied in the areas of the gastric, intestinal, and mesenteric microcirculation. The control group consisted of 18 patients with GP treated on a conventional protocol. The local microcirculation was assessed by means of orthogonal polarization spectral (OPS) scanning. Assessment of LMC parameters included the mean velocity of red blood cells (RBCs) and its flux, as well as the number of perfused capillaries (PS) and capillary diameter. The mean velocity of RBCs and its flux was significantly higher (p = 0.003 and p = 0.012, respectively) and the number of perfused capillaries was lower (p = 0.039) in patients treated with HDMT when compared to the control group. We showed for the first time that HDMT in the treatment of GP was associated with LMC changes. The results indicated that the use of HDMT for the initial and subsequent antibiotic therapy in GP was associated with improved tissue oxygenation.Stability of interleukin-1alpha 82fe58eafd

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