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Anesthesia & Analgesia and A&A Practice The IARS is committed to advancing the field of anesthesiology through a number of research and educational initiatives that benefit not only practicing anesthesiologists but also patients of all ages. Below please find some of the ways we expand our reach in these areas. Member Login for Journal Access Anesthesia & Analgesia, the flagship journal of the IARS and a benefit for IARS members, is published monthly to benefit current and future patients under the care of professionals engaged in the disciplines broadly related to anesthesiology, such as perioperative medicine, critical care, and pain management.The journal furthers patient care by reporting the fundamental advances in the sciences of these clinical disciplines and by documenting the clinical, administrative, and educational advances that guide therapy. Each issue features peer-reviewed articles on the latest advances in drugs, perioperative care, preoperative preparation, patient monitoring, pain management, patient safety and many other timely topics. A&A Practice, a benefit for IARS members, publishes high quality case reports with a focus on important teaching points, novel educational tools, and innovative solutions regarding patient safety, pain, quality and performance improvement, and global health management issues. All Echo Rounds and Echo Didactics articles publish exclusively in A&A Practice. The leading clinical journal in the field, Anesthesia & Analgesia is the official journal of the IARS and many professional medical societies. View Journal Affiliate Societies As part of our Centennial recognition, Anesthesia & Analgesia commissioned a series of papers focused on the future trajectory of anesthesiology, perioperative medicine, critical care, and pain medicine. These papers will be added to an online collection as they publish in Anesthesia & Analgesia throughout 2022. A&A: The Anesthesiologists Key Resource to Staying CurrentEstablished in 1922, Anesthesia & Analgesia provides the practice-oriented clinical research you need to keep current and deliver optimal care to your patients. Learn why you should be reading the journal and what role it serves for the anesthesia community. Advice from A&A Editors: What You Should Know about Submitting ManuscriptsEach year, over 1800 manuscripts are submitted for review. Of those manuscripts, about 35% are accepted for publication.The A&A Editors offer a few tips for preparing your manuscript for success. International Anesthesia Research Society90 New Montgomery Street, Suite 412San Francisco, CA 94105 Dr. Tuomas LiliusE-MailWebsiteGuest Editor1. INDIVIDRUG Research Program and Department of Pharmacology, Faculty of Medicine, University of Helsinki, FI-00290 Helsinki, Finland2. Department of Emergency Medicine and Services, Helsinki University Hospital and University of Helsinki, FI-00290 Helsinki, Finland3. Center for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 København, DenmarkInterests: novel opioids; ketamine; pharmacodynamics Prof. Dr. Teijo SaariE-MailWebsiteCo-Guest EditorDepartment of Anaesthesiology and Intensive Care, University of Turku and Turku University Hospital, Turku, FinlandInterests: pain therapy; opioids; pharmacometricsDear Colleagues,Most currently used analgesics act either by decreasing the excitability of peripheral nociceptors or through the inhibition of nociceptive signaling in the central nervous system (CNS). Almost all analgesics acting at the CNS level have anxiolytic properties, and a major problem related to their use is the development of dependency. The lack of efficacy, the adverse effects, and the opioid epidemic in the United States have created an urgent need for the development of novel, safer, and more effective analgesics. There are several novel targets under investigation, but even with our advanced understanding of pain pathophysiology, only a few new analgesics with a new mechanism of action have emerged so far during the 21st century. In addition to the discovery of novel analgesic targets, there is also a need for individualized tailoring and repurposing of the currently used analgesics in drug delivery aspects, as well as identifying patient groups benefiting most from therapy.New innovations in drug development and delivery contribute to continued improvement in anesthesia. Recent and evolving drug innovations are primarily focused on modifying the chemical structures of existing drugs or drug classes with the intent to improve their pharmacodynamic, pharmacokinetic, and adverse effect profiles. Alongside drug development, innovations in intravenous infusion delivery systems and pharmacometric modeling have fostered the development of target-controlled infusion regimens. The goal is to develop a closed-loop system wherein the measured output(s) isare used by a controller to determine a new input to the control system where the output is determined by the pharmacodynamic input(s). All these innovations will promote more precise and safer patient care, but there is an urgent need for large clinical trials to provide more evidence to ensure patient safety prior to widespread clinical implementation.The journal Pharmaceuticals warmly invites both reviews and original articles on anesthetic and analgesic drug discovery. This Special Issue includes clinical, translational, and preclinical manuscripts dealing with the development of novel candidates for anesthesia and analgesia, as well as repurposing old drugs for these indications.Prof. Dr. Tuomas LiliusProf. Dr. Teijo SaariGuest EditorsManuscript Submission InformationManuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.Please visit the Instructions for Authors page before submitting a manuscript.The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs).Submitted papers should be well formatted and use good English. Authors may use MDPIsEnglish editing service prior to publication or during author revisions.analgesicanestheticdrug discoveryrepurposingPublished Papers (10 papers)
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