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The overall objectives of this proposal are to continue our studies of the immunologic characteristics of idiopathic childhood nephrotic syndrome (idiopathic NS), to define the viral or bacterial nature of the infectious agent(s) of idiopathic NS, to identify and delineate all the cell types bearing antigen in idiopathic NS, and to define the nature of the immune response of idiopathic NS patients to the principal antigens of the bacterial and viral agents of idiopathic NS. (1) We will continue studies to isolate, purify, and characterize the antigenic components of the glomerulus, tubulo-interstitial cells, and plasma of idiopathic NS patients, and to determine the nature and specificity of their immune reactivity in idiopathic NS. (2) We will attempt to induce experimental allergic nephrotic syndrome in rats with four different antigens of interest in idiopathic NS: anti-brain antibody, anti-M2R antibody, brain extract, and ds-RNA. (3) We will attempt to immunize animals with human IgD antigens to elicit an anti-idiotypic response and to induce immunity against human T cells in order to "immunize out" circulating memory T cells.An intraocular lens (IOL) is a surgical implant used to replace the natural lens of an eye which has been damaged as a result of disease or trauma. Essentially, an IOL is a solid, thin, circular piece of plastic that is shaped and sized to closely fit within the capsular bag of the eye. The IOL may be inserted into the eye using a mechanical injector device, or "IOL injector."
A typical IOL injector utilizes a plunger having a hollow central passageway, usually having an O-ring seal at its base. The hollow central passageway of the plunger serves as a cannula to guide the plunger into the capsular bag. Upon insertion of the plunger through the center of a IOL and into the capsular bag, the plunger and IOL are pushed further into the capsular bag, through the small opening at the center of the IOL. Upon completion of the IOL injection, the plunger is withdrawn and the IOL is permanently adhered to the inner wall of the capsular bag.
The plunger of a typical 3125841983

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