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Engineering Mathematics. 4th Edition. By John Thomas. Engineering Mathematics. 4th Edition. By John Thomas. Download engineering mathematics solution manual. Solution manual, download engineering mathematics solution manual. Engineering Mathematics. 4th Edition. By John Thomas. Published by Institution of Mechanical Engineers. Source Edition: 2001. Book ID: 9780160611264. With engineering mathematics solutions manual for the. We use cookies to give you a better experience.[Multidrug resistance gene MDR1 in patients with AIDS-associated Kaposi's sarcoma].
The aim of this study was to estimate the presence of multidrug resistance gene MDR1 in the peripheral blood lymphocytes of patients with AIDS-associated Kaposi's sarcoma. The presence of MDR1 was analyzed by means of Southern blot hybridization. Blood samples of 38 patients were investigated. MDR1 was detected in 61.5% of patients. The highest frequencies of MDR1 presence were found in the following groups: patients with AIDS associated KS in the advanced stage of the disease (78.3%), patients with AIDS-KS-associated severe vascular pathology (54.5%), patients with AIDS-KS associated lymphangitis carcinomatosa (68.8%), patients with AIDS-KS associated angiocentric lymphoma (100%). The results obtained suggest that in the investigated patients there is an increased activity of the system responsible for drug efflux from the cells in the presence of the examined genes.-Vacancy
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