Textbook Of Fluid Dynamics F Chorlton Pdf Free 31 15
This is a text book for organic students. It is clear and concise. (iii) Poole, J., D' Arcy and Poole, K. .
A good text book for undergraduates and graduates, with a sufficient amount of detail.
Introduction {#s0005}
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Despite the prolific research that has been devoted to the study of nucleic acids and their metabolites, progress has been made at a relatively slow pace. It has long been apparent that chemical damage occurs to DNA, RNA and the cellular proteins in which they are embedded. However, the reason why some DNA and RNA molecules are resistant to damage and repair, while others are not is not at all obvious. The reason for these differences is also unclear. Is it a case of chance, or does DNA and RNA have a'master set' of nucleotides that makes them differ in stability and the damage they can survive?
However, in the last 20 years, a new paradigm has begun to emerge and by studying the nature of the damage and how it is repaired, this issue is being resolved. A major advance has been made by the discovery of base and sugar modified nucleotides, which greatly increase the chemical instability of the nucleotide and make it far more reactive. This is a significant issue, since these modified nucleotides are found in considerable abundance in the cell. It is not known how they arise, although DNA repair processes might be responsible.
The first review of nucleotide chemistry, published in the 1960s, by Watson and Crick[@bib1] stated: "The monomeric units of DNA and RNA are deoxynucleotides and ribonucleotides, respectively, and these are held together by hydrogen bonds. These building blocks are also the active units of the nucleotide in charge of information transfer."
By the 1980s, it was apparent that much was known about nucleotides and their role in DNA replication and transcription. To describe their function, another statement from the 1960s is useful: "The nucleic acids (RNA and DNA) are able to convey information, this is how they store genetic information (heredity), using the correct sequence of nucleotides to produce specific proteins (gene translation). The information they contain is stable, unless it is damaged or degraded."
In the 20 years since Watson and Crick wrote their book, we have learnt much about DNA replication, RNA transcription, translation, DNA
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