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Scientists do not yet fully understand what causes Alzheimers disease in most people. The causes likely include a combination of age-related brain changes, as well as genetic, environmental and lifestyle factors. The role of any of these factors in increasing or decreasing the risk of Alzheimers disease may vary from person to person. Alzheimers disease is a progressive brain disease. It is characterized by changes in the brain, including amyloid plaques and neurofibrillary tangles, or tau, that cause loss of neurons and their connections. These and other changes affect a persons ability to remember, think, and ultimately live independently. Aging and the Risk of Alzheimers Disease Older age does not cause Alzheimers disease, but it is the most important known risk factor for the disease. The number of people with Alzheimers disease doubles every 5 years after the age of 65. About a third of people over the age of 85 may have Alzheimers disease. Scientists are finding out how age-related changes in the brain can damage neurons and affect other types of brain cells, contributing to Alzheimers disease damage. These age-related changes include atrophy (shrinking) of certain parts of the brain, inflammation, damage to blood vessels, formation of unstable molecules called free radicals, and breakdown of energy production in cells. However, age is only one risk factor for Alzheimers disease. Many people live into their 90s or beyond without developing dementia. Alzheimers Genetics Many people worry about developing Alzheimers, especially if a family member has had it. A family history of the disease does not mean that you will definitely have it. But it may mean you have a better chance of it. The genes people inherit from their biological parents can affect their chances of developing Alzheimers disease. Genetic risk factors are changes or differences in genes that can affect the likelihood of developing a disease. These risk factors lead to some familial diseases. There are two types of Alzheimers disease, early-onset and late-onset. Both types have a genetic component. Learn about the causes of Alzheimers disease at NIA ADEAR Center for Alzheimers Disease and Related Dementia (ADEAR) The NIA ADEAR Center provides families, caregivers, and health care professionals with information and free print publications about Alzheimers disease and related dementia. ADEAR Center staff will respond to you by phone, email, and in writing, and direct you to local and national resources. This content is provided by NIHs National Institute on Aging (NIA). NIA researchers and other experts review this content to ensure it is accurate and up-to-date. Content revised: December 24, 2019 Alzheimers disease is a type of dementia that affects thinking, behavior, and the ability to perform everyday tasks. Alzheimers disease is associated with the accumulation of certain proteins and chemicals in the braScientists still do not fully understand what causes Alzheimers disease in most people. Causes likely include a combination of age-related brain changes, as well as genetic, environmental and lifestyle factors. The role of any of these factors in increasing or decreasing the risk of Alzheimers disease may vary from person to person. Alzheimers disease is a progressive brain disease. It is characterized by changes in the brain, including amyloid plaques and neurofibrillary tangles, or tau, which result in the loss of neurons and their connections. These and other changes affect a persons ability to remember and think, and ultimately live independently. Aging and the Risk of Alzheimers Disease Age does not cause Alzheimers disease, but it is the most important known risk factor for the disease. The number of people with Alzheimers disease doubles approximately every 5 years after age 65. About a third of people over the age of 85 may have Alzheimers disease. Scientists are learning how age-related changes in the brain can damage neurons and affect other types of brain cells to contribute to the damage caused by Alzheimers disease. These age-related changes include atrophy (shrinking) of certain parts of the brain, inflammation, damage to blood vessels, formation of unstable molecules called free radicals, and breakdown of energy production in cells. However, age is only one risk factor for Alzheimers disease. Many people live into their 90s and beyond without developing dementia. Alzheimers Genetics Many people worry about developing Alzheimers disease, especially if someone in their family has it. A family history of the disease does not necessarily mean you will have it. But it may mean youre more likely to develop it. The genes people inherit from their parents can affect their chances of developing Alzheimers disease. Genetic risk factors are changes or differences in genes that can affect the likelihood of developing a disease. These risk factors are why some diseases run in families. There are two types of Alzheimers disease, early-onset and late-onset. Both types have a genetic component. Learn more about the causes of Alzheimers disease NIA Center for Alzheimers and Related Dementia Education and Reference (ADEAR) The NIA ADEAR Center provides information and free print publications about Alzheimers disease and related dementias for families, caregivers, and health care professionals. ADEAR staff will answer phone, email and written questions and refer you to local and national resources. This content is provided by NIHs National Institute on Aging (NIA). NIA researchers and other experts review this content to ensure it is accurate and up-to-date. Content verified: December 24, 2019 Alzheimers disease is a type of dementia that affects a persons thinking, behavior, and ability to perform everyday tasks. Alzheimers disease is associated with the accumulation of certain proteins and chemicals in the bra

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