XforcekeygenInventorNesting201932bitfreedownloadexe
2x88x9214:Structure-dependent sequence and protease specificity of coronavirus main protease reveals a novel SARS-CoV-2 active site and explains drug-resistant clinical mutations201932bitexe2x88x9217:Activation of the human renin-angiotensin system, an important regulator of blood pressure, by the coronavirus main protease202030bitexe2x88x9213:Mutated COVID-19 proteases reveal pathogenic mechanisms that may underlie their drug resistance202030bitexe2x88x9216:Protease inhibitor design against the SARS-CoV-2 main protease202030bitexe2x88x9220:COVID-19: how the therapeutic landscape has changed
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An additional example of collection 200033 is available from the British Library. The collection is cited as N0.17.10.33 in the british library catalogue, and includes the following url address:  The british library. Cataloguing description. Accessed February 24, 2020.
The invention further provides methods for identifying compounds that are inhibitors of the coronavirus main protease. The methods comprise contacting the coronavirus main protease with a compound under conditions and for a time sufficient to allow the compound to interact with the coronavirus main protease, and determining whether the compound has interacted with the coronavirus main protease. The interaction can be determined using a detection system as described above. The contacting can be performed on a support, for example a surface. The support can be a biological or synthetic support, such as a plastic microtiter plate, a glass surface, or a silicon chip. Alternatively, the support can comprise glass or another material, coated with a biological or synthetic support, or a material, such as a silicon chip, that is not coated with a biological or synthetic support.
In preferred embodiments, the coronavirus main protease is contacted with a compound under conditions and for a time sufficient to allow a peptide or peptidomimetic to bind
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