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She wants revenge against the couple, who she believes is responsible for the death of her father.
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Category:American slasher films
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Category:American films about revengeChronic obstructive pulmonary disease (COPD) is the fourth leading cause of death in the United States, affecting over 15 million people and causing more than 100,000 deaths annually. COPD represents a serious health and economic burden on the population. Cigarette smoking is a major risk factor for the development of COPD, but there is considerable variation in the rate of decline in lung function among smokers. We hypothesize that genes involved in the regulation of proinflammatory signaling pathways that are critical to the development of COPD will be important in determining rates of decline in lung function. We will pursue the following Specific Aims to test this hypothesis: (1) To determine which SNPs in proinflammatory cytokines, chemokines, and chemokine receptors are most associated with COPD progression (rate of FEV1 decline) in a population-based cohort of smokers; (2) To develop a mechanism-based prediction model of COPD progression based on these SNPs; (3) To evaluate the role of two candidate genes, IKK1 and MST1, which have not been previously implicated in COPD, in COPD disease progression in a case-control study. We will leverage a cohort of 700 smokers who were prospectively followed for 3 years and have spirometric measurements at baseline and at 3-year intervals. The cohort will be genotyped for 32 SNPs in 20 candidate genes that are associated with COPD in prior studies. The genotype data will be used to assess the association between SNPs and rates of decline in FEV1. We will develop a prediction model using stepwise regression and bootstrap cross-validation. Finally, we will conduct case-control studies of I 3125841983
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