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Category:Dolby audioTumor necrosis factor alpha receptor 2 variants and early-onset sarcoidosis.
Sarcoidosis is a multisystem disorder characterized by granuloma formation. The serum level of tumor necrosis factor alpha (TNFalpha) is elevated in patients with sarcoidosis. TNFalpha exerts its effects via the membrane receptors TNFR1 and TNFR2. Recently, new polymorphisms of TNFR2 have been identified and linked to some autoimmune disorders. The aim of the present study was to investigate the association of TNFR2 variants with early-onset sarcoidosis. Genomic DNA was obtained from 69 patients with early-onset sarcoidosis and from 96 control subjects. Sequencing was performed to determine the genotype of the TNFR2 polymorphisms (C1234T, G1335C, and T1486C
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