Veer Movie Hindi Dubbed Download
Category:1958 films
Category:Indian films
Category:Films directed by Y. R. Swamy
Category:1950s Hindi-language films
Category:Indian black-and-white filmsThe objective of this work is to develop vaccines against proteinaceous diseases of humans and domestic animals, particularly Chlamydia trachomatis and Toxoplasma gondii. Chlamydia trachomatis is the etiologic agent of the blinding trachoma which is the leading cause of preventable blindness worldwide and ocular complications of systemic infection can be fatal. Since the 1950's, methods for diagnosis of chlamydial infections have improved significantly and proven to be a very useful method for epidemiologic studies. In contrast, tests for the most effective vaccines have failed. In the current application, work is proposed to develop a vaccine against chlamydial infection and clinical disease. We have developed an immunogenic chlamydial outer membrane protein (OMP) that includes a major outer membrane protein (MOMP) as well as two minor outer membrane proteins (MOMP-2, PmpG). A cocktail of these proteins was shown to be protective against trachoma in a mouse model. The proposed studies will characterize the antichlamydial immunity induced by this vaccine, determine whether the immune response depends on the dosage and route of immunization, and determine the duration of protection. In addition, these studies will assess the vaccine's ability to reduce the duration of infection. These studies will be carried out in macaques since the species is the closest relative to humans and the predominant reservoir of infection. A second goal of this work is to develop a vaccine against toxoplasmosis, an important opportunistic pathogen in AIDS patients. Toxoplasma gondii has a significant impact on public health worldwide and a vaccine would be a great public health achievement. We have developed a unique tachyzoite surface antigen, TgSAG-1, that is highly immunogenic in mice and other species including non-human primates. Further evaluation of TgSAG-1 in the macaque model will be pursued. {
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