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 or use of marker arrays for linkage analysis as a variation of the traditional linkage study designs.
Authors' contributions
=======================
FJK and JW conceptualised and coordinated the study, assisted in the design of the study and wrote the paper; FJK selected the families, extracted DNA from the families and the DNA samples for genotyping the markers, coded the data and performed the data analysis under the supervision of JW. Both authors read and approved the final manuscript.
Supplementary Material
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Continuous visual analogue scale for the evaluation of anti-reflux drugs in humans.
A randomized crossover study was carried out in 20 patients with gastro-oesophageal reflux disease to compare the effects of antisecretory treatment using the omeprazole and ranitidine formulations, on the oesophageal perception of'reflux' as measured by a visual analogue scale. The patients were tested twice, before and after 4 days' treatment with each antisecretory agent. The studies were
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