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Important update: CDC health facilities have updated selected ways health care systems are working effectively in response to vaccination against Covid-19. Learn more about pediatric healthcare facilities The epidemiology of Covid-19 in the pediatric population has been difficult to determine for a number of reasons, including the high rate of asymptomatic infections and differences in testing rates between children and adults1,2. Studies have shown that compared to adults, children may have similar or higher rates of SARS-CoV-2 infection, but are more likely to experience asymptomatic infection or less severe symptoms3,4,5. The incubation period for Covid-19 is believed to be 14 days, but studies show that incubation periods can vary depending on the variant of the virus. A study conducted on transmission of the high Delta variant showed a mean incubation time of 4.3 days, while the remaining variants, including alpha and beta variants, had a mean incubation time of 5 days6. Studies conducted during high transmission rates of the Omicron variant showed that the average incubation period was 3-4 days7,8. The most common symptoms of COVID-19 in children are fever and cough, but many children may experience a sore throat, runny nose, headache, fatigue, shortness of breath, or gastrointestinal symptoms, including nausea, vomiting, or diarrhea 9,10,11 ,12 . A few case studies conducted during high-level transmission of the Omicron variant have shown a significant increase in crossbreeding, while reducing the incidence of all other respiratory viral pathogens known to cause croup13,14. Signs and symptoms of Covid-19 in children can be similar to other infections and non-infectious processes, so symptom-based screening for SARS-CoV-2 identification in children is particularly difficult15. Testing for SARS-CoV-2 should be considered even in children with mild symptoms. Most children with SARS-CoV-2 infection have asymptomatic or mild disease, but some children are at risk for severe disease, including hospitalization, ICU admission, invasive mechanical ventilation, and death16. Research shows that some underlying medical conditions, including obesity; diabetes; cardiac, pulmonary and neurological disorders; and medical complexity increase the risk of severe COVID-1917,18,19,20, and more than one pre-existing medical condition is associated with an increased risk of severe disease18,21. Studies have shown that age may also be associated with the risk of severe disease, and when looking at children older than 7 days and <18 years, follow-up data show that infants have a disproportionate number of severe acute cases of COVID-1922. cases. Similarly, a study of hospitalization rates in children aged 0-17 years showed that the rate of hospitalizations related to COVID-19 in children and adolescents during the Omicron period was four times higher than in the peak Delta period and in children aged 0 years and older. .Important update: The CDCs health facilities have updated some of the ways health systems are working effectively in response to the Covid-19 vaccination. Learn more about childrens health facilities. The epidemiology of Covid-19 in the pediatric population has been difficult to quantify for several reasons, including the high incidence of asymptomatic infections and the disparity in testing rates between children and adults1,2. Studies have shown that children may have a similar or higher incidence of SARS-CoV-2 infection compared to adults, but are more likely to have asymptomatic infection or have less severe symptoms3,4,5. The incubation period for Covid-19 is thought to be up to 14 days, but studies show that incubation periods can vary depending on the variant of the virus. In a study conducted during a high transmission rate for the Delta variant, the mean incubation time was 4.3 days, while the other variants, including alpha and beta, showed a mean incubation time of 5 days6. In studies conducted at high transmission rates of the Omicron variant, the average incubation period was 3-4 days7,8. The most common symptoms of COVID-19 in children are fever and cough, but many children may experience sore throat, runny nose, headache, fatigue, shortness of breath, or gastrointestinal symptoms including nausea, vomiting, or diarrhea 9,10,11 ,12. Some case studies conducted during the high transmission rate of the Omicron variant showed a significant increase in sputum while reducing all other respiratory viral pathogens known to cause sputum13,14. Symptoms of Covid-19 in children can be similar to those of other infections and non-infectious processes, making symptom-based screening to identify SARS-CoV-2 in children particularly difficult15. Testing for SARS-CoV-2 should be considered even in children with mild symptoms. Most children with SARS-CoV-2 infection have asymptomatic or mild disease, but some children are at risk of developing severe disease, including hospitalization, ICU admission, invasive mechanical ventilation, and death16. Research has shown that some underlying health conditions, including obesity; diabetes; cardiac, pulmonary and neurological disorders; and medical complexity increases the risk of severe COVID-1917, 18, 19, 20 and more than one preexisting comorbid disease is associated with an increased risk of severe disease 18, 21. Studies have shown that age may also be associated with the risk of severe disease and in When evaluating surveillance data in children older than 7 days and <18 years, a disproportionately high incidence of severe acute illness of Covid-1922 was reported in infants. Similarly, a study of hospitalization rates for children aged 0–17 years showed that child and adolescent hospitalization rates related to COVID-19 during the Omicron period were four times higher than during the peak delta period and for children aged 0 years. and older.

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