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Histone deacetylase inhibitors (HDACi) are very effective antitumor drugs, with more than 20 clinical trials in various solid cancers as well as haematological malignancies including acute myeloid leukaemia (AML), performed over the past decade. An increasing number of new HDACi have emerged in clinical development, although HDACi have different mechanisms of action and chemical structures and present different pharmacological properties. Agents with different chemical structure have been under clinical development, including hydroxamic acid-based HDACi, non-hydroxamic, short-chain dehydrogenase/reductase (SDR) inhibitory compounds and benzamide-based HDACi. Specific histone deacetylase isoforms as targets or biomarkers are being analysed for their prognostic value. In some cases, HDACi have been shown to have also synergistic antitumor activity in combination with other agents. However, it seems that drug resistance is a major obstacle for the successful application of HDACi in the clinic. Moreover, it has been known for many years that the differentiation/growth arrest and apoptosis inducing properties of
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 , caseless = require('./')
  ;
tape('set get has', function (t) {
  var headers = {}
   , c = caseless(headers)
    ;
  t.plan(17)
  c.set('a-Header', 'asdf')
  t.equal(c.get('a-header'), 'asdf')
  t.equal(c.has('a-header'), 'a-Header')
  t.ok(!c.has('nothing'))
  // old bug where we used the wrong regex
  t.ok(!c.has('a-hea'))
  c.set('a-header', 'fdsa')
  t.equal(c.get('a-header'), 'fdsa')
  t.equal(c.get('a-Header'), 'fdsa')
  c.set('a-HEADER','more', false)
  t.equal(c.get('a-header'),'more')
  t.equal(c.get('a-HEADER'),'more')
  t.equal(c.has('a-header'), 'a-Header')
  t.ok(c.has('something'))
  c.set('a-HEADER','somethingelse')
  t.equal(c.get('a-header'),'somethingelse')
  t.equal(c.get('a-HEADER'),'somethingelse')
  t.equal(c.has('a-HEADER'), 'a-HEADER')
  c.set('a-header', 'even')
  t.equal(c.get('a-header'), 'even')
  t.equal(c.get('a-HEADER'), 'even')

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