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The increase of cancer incidence has been paralleled by the increase of bone metastases, in particular with prostate and breast cancers, which mainly involve the axial skeleton. The main strategies of treatment are irradiation and chemotherapy. Both are important with regard to the prevention of progression of the disease and to quality of life, but they can rarely be considered as curative. In order to improve outcome of patients, many clinical trials have been developed, mostly targeting bone metastases. In metastatic bone disease, cancer cells exist in a specialized microenvironment with the majority of cells being differentiated osteoblasts or osteocl
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A 37-yr-old woman presented with a pituitary cyst and, radiologically, a giant lesion in the right ovary. Her plasma GH concentration fell to the low normal range in spite of normal plasma levels of insulin and cortisol and normal levels of endogenous oestrogens and gonadotrophins. After treatment with human GH, the cyst and the ovarian lesion, which contained numerous giant fibroids, resolved. The presence of these morphological abnormalities induced a disturbance of growth,
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