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ROSETTA {#S3}
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ROSETTA ([www.rosetta.org]( is a web-based interface that automatically retrieves *in vitro* or *in vivo* data from the literature and displays this information along with a set of tools, such as: similar studies; a list of mutants with the same phenotype; and clustering of mutations according to the phenotype, when applicable.
To initiate a search, simply enter the query terms in the text box above the browse page, and select a category to sort by. Once the search is completed, the results will be displayed in a table with links to the referenced articles. The results can be searched by either author, search term, or category. Clicking on the link for a particular article will display a simple page that will allow for further analysis of the article.
Once an article has been selected, several tools are available to assist with the analysis of the article:
In Figure [1](#F1){ref-type="fig"}, we illustrate the example of performing a literature search using a sequence identifier (i.e., Pg1) in the PubMed search.
![**An example of using ROSETTA to perform a literature search**. **(A)** Results of the search are shown. The user can see the total number of results and also click on a row (in this case, the one with sequence identifier Pg1), which will take the user to the corresponding article. **(B)** In this example, the user then wants to identify which cofactors are required for substrate binding. In this instance, clicking on the "Fucus" option will display a second page that lists all of the mutations available for the Fucus-containing protein. **(C)** As is evident from the results displayed, not all of the Fucus-containing proteins require K and Z. Therefore, the user could perform a second literature search in PubMed using the gene symbols for the proteins that do require K or Z.](fgene-02-00095-g001){#F1}
For convenience, a list of cofactors that are not shown in Figure [1](#F1){ref-type="fig"} is available by clicking on the "cofactors" button. This will take the user to a list of 15 cofactors that have been 3125841983

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