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• Request: Preview request parameters, send request, generate response and save the response
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• Assertions: Validate basic attributes of a response
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• Export by: Export data banksInhibition of human myeloperoxidase activity by esculin and coumarins from the moss Polytrichum commune.
The crude polysaccharide fraction of the edible moss Polytrichum commune (Polytrichaceae), rich in polysaccharides and coumarins, has shown anti-inflammatory activities. We purified it by three chromatographic steps that gave one major active compound: a neutral oligosaccharide with a molecular mass of 1 kDa. Its structure, obtained by NMR, MS, and fragmentation data, is the esculin. The kappa/iota ratio of this esculin was determined by MS/MS. The compounds, e.g., chalcones, contained two to four methylthio groups in their structure. The effect of some coumarins and of esculin on the catalytic activity of human neutrophil and monocyte-derived myeloperoxidase (MPO) was evaluated. The esculin showed an inhibition of the enzymatic activity of MPO, with 50% inhibitory concentration of 3.6 microg/mL. The following coumarins were also active: 13-O-benzoylscoumarin, 2,3-dihydro-13-hydroxy-3-methyl-2-oxo-2H-1-benzopyran-5-one, 2,3-dihydro-13-hydroxy-3-methyl-2-oxo-2H-1-benzopyran-5-thione, and 2,3-dihydro-13-hydroxy-3-methyl-2-oxo-2H-1-benzop
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Sample API Tests user-interface. When you click on ‘Test’ a simulator is deployed on the web. Your tests are run and you can view the results in real time and from your test server. It is based on BizReactorSYDNEY (Reuters) - The number of babies born with hypoxic ischemic encephalopathy (HIE) due to brain injury after premature birth has risen seven-fold in Australia’s most populous state of New South Wales, birth data show.
Data from the state health department showed that 6,391 babies were born in 2013 with HIE, compared with 1,417 in 2009.
The figures were obtained through a freedom of information request and do not include home births.
HIE is an extremely serious brain injury that the World Health Organisation has classified as a level four disability.
The condition is caused when a baby is delivered prematurely and the first
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