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Dec 8, 2013 
 Kremlok 4bbf87e9c4 
oči lijevi kraj glave Nov 9, 2013 
 aktivni ejekt 6d9e56ac28 
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. [RT]
[Evaluation of glucose metabolism in relation to motor neuron diseases].
Diabetes mellitus is known to be a risk factor of amyotrophic lateral sclerosis (ALS). Previous studies on diabetes mellitus and its complications in ALS patients have given controversial results. In order to clarify the effect of diabetes mellitus on the clinical course of ALS, we studied glucose metabolism in patients with ALS. In 1,629 Japanese ALS patients, consisting of 1,547 sporadic ALS patients and 82 familial ALS patients, we examined the serum levels of F- and I-glucose, HbA1c, and glycated albumin (GA) which were the indicators of early-phase hyperglycemia. The prevalence of diabetes mellitus (DM) in Japanese ALS patients was 19.1% (271/1,547). The frequency of DM was not significantly different between familial and sporadic ALS. However, the mean age of patients with DM was significantly higher than those without DM. The mean serum levels of F- and I-glucose, HbA1c, and GA were significantly higher in DM ALS patients than those without DM. There were no significant differences in the serum levels of F- and I-glucose, HbA1c, and GA between familial and sporadic ALS patients with DM. Patients with DM had significantly lower forced vital capacity (FVC) and higher rate of bulbar involvement than those without DM. These results suggest that DM might have a negative effect on the progression of ALS. the surface is almost as low as the LUMO~S~, as observed in the 2D-NPD measurements. This is because the dipole moments of the isomers become more perpendicular to the surface, and the sp^2^ hybridized carbons take over the dangling carbon bonds, with less hybridization with the graphene edge. This would be reasonable for the thermal stabilization of the isomers in the gas phase. Theoretically, the isomer with the strong dipole moment should be lower in energy than the isomer with the weak dipole moment because of the short distance of the surface dipole and the isomer dipole, which is
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