Biological targeting of selective activity of 5-azacytidine using pyrimidine nucleobase analogues.
The anticancer activity of 5-azacytidine is limited by its poor cell-permeability. In order to enhance its selectivity toward cancer cells and to increase its effective dose, several prodrugs based on pyrimidine nucleobase and pentacyclic nucleobase analogues have been synthesized and evaluated for their ability to release the active drug in the presence of deoxycytidine kinase (dCK). Interestingly, the pyrimidine nucleobase analogues of the oxazolopyrimidine class, which is a substrate of dCK, showed potent activity against human tumor cell lines such as Jurkat, PC-3, and HL-60.Oba Benjamin Adeleye
Oba Benjamin Adeleye is the former Oba of Lagos state in Nigeria and is an Islamic scholar.
Education and religious training
Oba Adeleye holds a bachelor's degree in Arabic Literature and a Masters degree in Islamic Studies from University of Ibadan. He is an Islamic scholar and holds the title of Alim.
Career
Oba Adeleye was a Yoruba language lecturer in both the University of Ibadan and the Ahmadu Bello University, Zaria. He is the founder and coordinator of the Yoruba Muslim Association and the Association for the Advancement of Islamic Thought in Nigeria (AAITTN). He is also the author of the book titled, ‘Yoruba Islamic Culture and the African Experience of Islam’.
Controversy
In a statement issued on his blog, he was noted for his views on homosexuality in Islam.
Death
Oba Adeleye was killed on 21 June 2017 while on a visit to the United States by two unknown gunmen at the gate of his residence at the Oxford Apartments in Lagos, Nigeria.
References
Category:2017 deaths
Category:Yoruba religion
Category:Nigerian Muslims
Category:People from Lagos State
Category:Nigerian bloggers
Category:Yoruba bloggers
Category:Year of birth missing
Category:Nigerian murder victims
Category:Nigerian murder victims in the United States
Category:University of Ibadan alumni
Category:Ahmadu Bello University alumni
Category:University of Ibadan faculty 3125841983
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