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Important tip: much is always used together with an uncountable noun (like oil or water) while many is always used with nouns that are countable (like table or computer)Its also good to know that too means that you dont like the situation, for example, There is too much food on my plate means that youre not happy about it.Heres an exercise to help you practice. Good luck!Lesson by Seb, teacher at EC Cape Town English schoolLink: uncountable and countable nouns Bacher, C. P., et al. Transient colocalization of X-inactivation centres accompanies the initiation of X inactivation. Nature Cell Biology 8, 293-299 (2006) doi:10.1038ncb1365 (link to article) Borsani, G., et al. Characterization of a murine gene expressed from the inactive X chromosome. Nature 351, 325–329 (1991) doi:10.1038351325a0 (link to article) Boumil, R. M., & Lee, J. T. Forty years of decoding the silence in X-chromosome inactivation. Human Molecular Genetics 10, 2225–2232 (2001) Brockdorff, N., et al. Conservation of position and exclusive expression of mouse Xist from the inactive X chromosome. Nature 351, 329–331 (1991) doi:10.1038351329a0 (link to article) ———. The product of the mouse Xist gene is a 15 kb inactive X-specific transcript containing no conserved ORF and located in the nucleus. Cell 71, 515–526 (1992) Brown, C. J., et al. A gene from the region of the human X inactivation centre is expressed exclusively from the inactive X chromosome. Nature 349, 38–44 (1991) doi:10.1038349038a0 (link to article) ———. The human XIST gene: Analysis of a 17 kb inactive X-specific RNA that contains conserved repeats and is highly localized within the nucleus. Cell 71, 527-542 (1992) Carrel, L., & Willard, H. F. X-inactivation profile reveals extensive variability in X-linked gene expression in females. Nature 434, 400–404 (2005) doi:10.1038nature03479 (link to article) Clemson, C. M., et al. XIST RNA paints the inactive X chromosome at interphase: Evidence for a novel RNA involved in nuclearchromosome structure. Journal of Cell Biology 132, 259–275 (1996) Costa, F. F. Non-coding RNAs, epigenetics, and complexity. Gene 410, 9–17 (2008) Duret, L., et al. The Xist RNA gene evolved in eutherians by pseudogenization of a protein-coding gene. Science 312, 1653–1655 (2006) Graves, J. A. Sex chromosome specialization and degeneration in mammals. Cell 124, 901–914 (2006) Ham, A. L., et al. Does genotype predict phenotype in Rett syndrome? Journal of Child Neurology 20, 768–778 (2005) Hornecker, J. L., et al. Meiotic sex chromosome inactivation in the marsupial Monodelphis domestica. Genesis 45, 696–708 (2007) Huynh, K. D., & Lee, J. T. X-chromosome inactivation: a hypothesis linking ontogeny and phylogeny. Nature Reviews Genetics 6, 410–418 (2005) doi:0.1038nrg1604 (link to article) Johnston, C. M., et al. Large-scale population study of human cell lines indicates that dosage compensation is virtually complete. PLoS Genetics 4, e9 (2008) Lee, J. T. Disruption of imprinted X inactivation by parent-of-origin effects at Tsix. Cell 103, 17–27 (2000) Lee, J. T., & Lu, N. Targeted mutagenesis of Tsix leads to nonrandom X inactivation. Cell 99, 47–57 (1999) Lee, J. T., et al. Tsix, a gene antisense to Xist at the X-inactivation centre. Nature Genetics 21, 400–404 (1999) (link to article) Liao, D. J., et al. Novel perspective: Focusing on the X chromosome in reproductive cancers. Cancer Investigation 21, 641–658 (2003) Lucchesi, J. C., et al. Chromatin remodeling in dosage compensation. Annual Review of Genetics 39, 615–651 (2005) Luikenhuis, S., et al. Antisense transcription through the Xist locus mediates Tsix function in embryonic stem cells. Molecular and Cellular Biology 21, 8512–8520 (2001) Lyon, M. F. Gene action in the X-chromosome of the mouse (Mus musculus L.). Nature 190, 372–373 (1961) doi:10.1038190372a0 (link to article) Marahrens, Y., et al. Xist-deficient mice are defective in dosage compensation but not spermatogenesis. Genes & Development 11, 156–166 (1997) Martin, G. R., et al. X-chromosome inactivation during differentiation of female teratocarcinoma stem cells in vitro. Nature 271, 329–333 (1978) (link to article) Namekawa, S. H., et al. Sex chromosome silencing in the marsupial male germ line. Proceedings of the National Academy of Sciences 104, 9730–9735 (2007) Ogawa, Y., et al. Intersection of the RNA interference and X-inactivation pathways. Science 320, 1336–1341 (2008) Okamoto, I., & Heard, E. The dynamics of imprinted X inactivation during preimplantation development in mice. Cytogenetic and Genome Research 113, 318–324 (2006) Penny, G. D., et al. Requirement for Xist in X chromosome inactivation. Nature 379, 131–137 (1996) doi:10.1038379131a0 (link to article) Rastan, S., & Robertson, E. X chromosome deletions in embryo-derived (EK) cell lines associated with lack of X chromosome inactivation. Journal of Embryology and Experimental Morphology 90, 379–388 (1985) Sado, T., et al. Regulation of imprinted X-chromosome inactivation in mice by Tsix. Development 128, 1275–1286 (2001) Sleutels, F., & Barlow, D. P. The origins of genomic imprinting in mammals. Advances in Genetics 46, 11–163 (2002) Stavropoulos, N., et al. A functional role for Tsix transcription in blocking Xist RNA accumulation but not in X-chromosome choice. Proceedings of the National Academy of Sciences 98, 10232–10237 (2001) Wutz, A., & Jaenisch, R. A shift from reversible to irreversible X inactivation is triggered during ES cell differentiation. Molecular Cell 5, 695–705 (2000) Xu, N., et al. Transient homologous chromosome pairing marks the onset of X inactivation. Science 311, 1149–1152 (2006) doi:10.1126science. ———. Evidence that homologous X-chromosome pairing requires transcription and Ctcf protein. Nature Genetics 39, 1390–1396 (2007) doi:10.1038ng.2007.5 (link to article).

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