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I want to extract the beginning, the end and all rows that contain the same letter-number combination from a dataframe.
In the example above I want to extract the row with the letter 'a' and 'a' for the beginning and end.
When the "letter"-number-combination is present in the file, I want to extract all rows that contain the same "letter"-number combination.
A:
Use Series.duplicated with regex=True for get all match of substrings:
s = df[df['CODE'].str.contains('a')].reset_index(drop=True)
#
#print (df[df['CODE'].str.contains('a')].index)
#[1]    21
print (s['CODE'].str.split('a').str[0])
['e', 'a', 'a']
print (s[s['CODE'].str.contains('a')])
CODE
e      a    a
Name: CODE, dtype: object
21     e    a    a
Last is possible filter by Series.isin:
df = df[df['CODE'].str.contains('a')].reset_index(drop=True)
print (df[df['CODE'].str.contains('a')].drop_duplicates(subset='CODE', keep='first'))
   CODE
1    a    a
21   e    a    a
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